反应详情

To a mixture of 3-trimethylsilylbenzylalcohol (3.60 g, 20 mmol) and pyridium dichromate (11.29 g, 30 mmol) in dichloromethane (60 ml) at 0° C. was added 3 Å molecular sieve powder (16 g) and anhydrous acetic acid (2 ml). Then the reaction was allowed to react 30 min at room temperature, stirred 20 min with celite (10 g), filtered and evaporated under reduced pressure. The residue was treated with diethyl ether (50 ml), filtered through MgSO4 and concentrated. 3-trimethylsilylbenzaldehyde was purified by distillation.

1. customto react 30 min at room temperature
2. filtrationfiltered
3. customevaporated under reduced pressure
4. additionThe residue was treated with diethyl ether (50 ml)
5. filtrationfiltered through MgSO4
6. concentrationconcentrated
7. distillation3-trimethylsilylbenzaldehyde was purified by distillation