Hydrochloric Acid → HCID 86751679, compound

Participants

Reaction Steps

Combine 1-(4-chlorobutoxy)phenyl-1,2-diphenyl ethanol (17.0 kg, 20.2 mol) and methanol (30 L). Add aqueous 3M hydrochloric acid solution (40 L). Heat to reflux. After 2 hours, remove most of the methanol by distillation and cool the aqueous reaction mixture. Extract with chloroform. Extract the organic layer with aqueous saturated sodium carbonate solution. Separate the organic layer and evaporate in vacuo to give (E and Z)-1-(4-chlorobutoxy)phenyl-1,2-diphenyl ethylene.

Provenance & Evidence