HCID 20524940, compound → HCID 21469979, compound

HRID 1938772Notes

Reaction equation

HRID 1938772 reaction equation
N1C2=C3N=CN=C3C=CC2=CC=C(C(O)=O)N=1.[CH:18]1[N:22]2[C:23]3[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=3[CH:25]=[N:26][CH2:27][C:21]2=[CH:20][N:19]=1>>[CH:18]1[N:22]2[C:23]3[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=3[CH2:25][N:26]=[CH:27][C:21]2=[CH:20][N:19]=1

Participants

3

Reactant 2

HCID 20524940HCID 20524940, compoundHCID 67703715HCID 67703715, compound

Product 1

HCID 21469979HCID 21469979, compound

Procedure

The process described in U.S. Pat. No. 4,280,957 comprises decarboxylating the corresponding imidazo-benzodiazepine-carboxylic acid at 100°-350° C., optionally in the presence of a solvent and a catalyst. This process has the disadvantage that in addition to the desired 4H-imidazo[1,5-a][1,4]-benzodiazepine derivative of formula I there is obtained a considerable amount of the corresponding isomeric 6H-imidazo[1,5-a][1,4]-benzodiazepine derivative, which requires an expensive re-isomerization.

Workup

  1. customat 100°-350° C.

Sources & evidence

ORD record
ord-45c52ce9141146b9a01e1345137a1135
Source dataset
uspto-grants-1997_12
Patent number
US05693795

Reaction notes

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