2-Methoxyethanol → HCID 178445544, compound

Participants

Reaction Steps

1-Hydroxy-1,4-dimethylbutylphosphonous acid prepared as described in Example 8 (0.166 g. 0.001M), 2-methoxyethanol (0.076 g. 0.001M) and dimethylaminopyridine (0.01 g.) are stirred in THF (5 ml.) at 5° C. Dicyclohexylcarbodiimide (0.23 g., 0.001M) is added portionwise and the mixture is stirred for 3 hours. Ether (10 ml.) is added and the dicyclohexylurea is filtered off. The filtrate is evaporated and the residue is dissolved in chloroform and washed with water. Evaporation of the chloroform gives an oil which is purified on silica using ethyl acetate as eluant. There is obtained 2-methoxyethyl (1-hydroxy-1,4-dimethylbutyl)phosphinate.

Provenance & Evidence