Methanol → HCID 86751694, compound

Participants

Reaction Conditions

Reaction Steps

Crude crystals of 7-[(7-(S)-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (5 g) were added to 150 ml of an aqueous methanol having a water content of 1% or less to form a slurry. The slurry was stirred at 25° C. for 3 days. The crystals were collected by filtration and dried at room temperature under reduced pressure until it was confirmed that the weight became constant to give 4.5 g of the title compound.

Provenance & Evidence