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Tetrabromophthalic anhydride → 2,3,4,5-Tetrabromo-6-[(4-chloro-2-fluoro-5-isopropoxycarbonyl-phenyl)carbamoyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrabromophthalic anhydride | HCID 12443 | — |
| 反応物 | Propan-2-yl 5-amino-2-chloro-4-fluorobenzoate | HCID 13519894 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2,3,4,5-Tetrabromo-6-[(4-chloro-2-fluoro-5-isopropoxycarbonyl-phenyl)carbamoyl]benzoic acid | HCID 507315 | — |
反応手順
Tetrabromophthalic anhydride (6.67 g, 0.014 mole) and 1-methylethyl 5-amino-2-chloro-4-fluorobenzoate (3.33 g, 0.014 mole) were heated to reflux with stirring in about 150 ml of toluene, then left overnight at room temperature. Filtration of the reaction mixture gave the title compound, m.p. 160°-165° C. (decomp.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05693827 |
| 出典データセット | uspto-grants-1997_12 |
| ORD ID | ord-e3dd39b6e2654b0a98d17a918d348e25 |
| 出典メモ | uspto-grants-1997_12 |