HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Methyl-5,6-dihydro-1,4-dioxine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2,2,2-Trifluoro-1-(3-methyl-5,6-dihydro-1,4-dioxin-2-yl)ethan-1-one | HCID 15376173 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Methyl-5,6-dihydro-1,4-dioxine-2-carboxylic acid | HCID 15376174 | 69.4% |
Reaction Steps
A mixture of 1-(5,6-dihydro-3-methyl-1,4-dioxin-2-yl)-2,2,2-trifluoroethanone (12 g, 0.06 mole) and powdered potassium hydroxide (6 g, 0.1 mole) was refluxed in toluene (200 ml) for 7 hours. The mixture was cooled, acidified with 6N hydrochloric acid, and the solid precipitate, crude 5,6-dihydro-3-methyl-1,4-dioxin-2-carboxylic acid (6 g, 60% yield) collected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693827 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-33faeb40ad9247f3b0b1b8c49c5264bc |
| Source note | uspto-grants-1997_12 |