HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivaloyl chloride → Isopropyl 2-chloro-5-((2,2-dimethylpropanoyl)amino)-4-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | Propan-2-yl 5-amino-2-chloro-4-fluorobenzoate | HCID 13519894 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | Isopropyl 2-chloro-5-((2,2-dimethylpropanoyl)amino)-4-fluorobenzoate | HCID 361505 | 79% |
Reaction Steps
A solution of trimethylacetyl chloride (2.53 g, 0.021 mole) and 1-methylethyl 5-amino-2-chloro-4-fluorobenzoate (4.62 g, 0.020 mole) in methyl ethyl ketone was stirred at room temperature for 16 hours and then refluxed for 2 hours. The solvent was removed and the residue triturated with diethyl ether to give a tan solid, m.p. 81°-83° C. (5.0 g, 79% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693827 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-8c4211095eae4913b9672c2cd7b491ec |
| Source note | uspto-grants-1997_12 |