HCID 21470319, compound → HCID 178447725, compound

HRID 1938873Notes

Reaction equation

HRID 1938873 reaction equation
C1([Si:7]2([CH:20](C)[CH2:21][CH2:22][CH3:23])[CH2:12][CH2:11][CH:10]([CH:13]3[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]3)[CH2:9][CH2:8]2)C=CC=CC=1.[F:25][C:26]1[CH:27]=[C:28]([Mg]Cl)[CH:29]=[CH:30][C:31]=1[F:32].F[C:36]1C=C(C2CCC([Si]3(CCC(C)C)CCCCC3)CC2)C=CC=1F>>[F:25][C:26]1[CH:27]=[C:28]([CH:16]2[CH2:15][CH2:14][CH:13]([C@H:10]3[CH2:9][CH2:8][Si@H:7]([CH2:20][CH2:21][CH:22]([CH3:23])[CH3:36])[CH2:12][CH2:11]3)[CH2:18][CH2:17]2)[CH:29]=[CH:30][C:31]=1[F:32]

Participants

4

Reactant 3

HCID 21470319HCID 21470319, compoundHCID 131720348HCID 131720348, compoundHCID 178505845HCID 178505845, compound

Product 1

HCID 178447725HCID 178447725, compound

Procedure

The general procedure of Example 6 was repeated using 4-(4-phenyl-4-(methylbutyl)-4-silacyclohexyl)cyclohexanone and 3,4-difluorophenylmagnesium chloride, thereby obtaining trans, trans-4-(4-(3,4-difluorophenyl)cyclohexyl-1-(3-methylbutyl)-1-silacyclohexane. The results of NMR and IR analyses are shown below.

Workup

  1. customThe results of NMR and IR analyses

Sources & evidence

ORD record
ord-b90fe6615edc498783228eadf43b03ac
Source dataset
uspto-grants-1997_12
Patent number
US05693841

Reaction notes

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