Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

A method for the production of E-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3 '-hydroxyphenyl)-2-phenyl-1-butene of formula (I) ##STR9## which comprises the steps of a) heating the compound of formula (II) ##STR10## where R is an easily hydrolyzable protecting group at a temperature within the range of 70°-80° C. for a time within the range of 4-6 hours in the presence of an organic solvent and HCl gas and then cooling the reaction to a temperature within a range of -5° to 5° C. for a time within the range of 10-14 hours to obtain E/Z-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl) -2-phenyl-1-butene×hydrochloride of formula (IIIa), and ##STR11## b) heating the compound of formula(IIIa) at a temperature within the range of 50°-60° C. for a time within the range of 10-24hours in the absence of an organic solvent and in the presence of 40-50% by volume suifuric acid or 32-37% hydrochloric acid, and alkalinizing the reaction mixture to obtain the compound according to formula (I).

Provenance & Evidence