反应详情

温度

-78 °C

A solution of 3,4,4-trifluoro-3-butenoyl chloride (2.4 g, 0.0151 mole) in dry ether (20 mL) is treated dropwise with anhydrous hydrazine (0.48 g, 0.15 mole) with stirring at -78° C. The mixture is allowed to reach room temperature and the white precipitate is filtered and dissolved in ethyl acetate. The ethyl acetate solution is washed with 5% sodium bicarbonate and dried. Evaporation of the solvent gave 1.1 g of the desired product as a white solid, a 47% yield. m.p. 191°-193° C.

1. customto reach room temperature
2. filtrationthe white precipitate is filtered
3. dissolutiondissolved in ethyl acetate
4. washThe ethyl acetate solution is washed with 5% sodium bicarbonate
5. customdried
6. customEvaporation of the solvent