HCID 131719462, compound → HCID 86751697, compound

HRID 1938917Notes

Reaction equation

HRID 1938917 reaction equation
[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C@@H:7]([CH2:8][CH:9]=[C:10]4[C@:15]3([CH3:16])[CH2:14][CH2:13][C:12](=[O:20])[NH:11]4)[C@@H:6]1[CH2:5][CH2:4][C@@H:3]2[O:21][CH2:22][C:23]([OH:25])=[O:24]>C(O)(=O)C.[Pt]=O>[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C@@H:7]([CH2:8][CH2:9][C@@H:10]4[C@:15]3([CH3:16])[CH2:14][CH2:13][C:12](=[O:20])[NH:11]4)[C@@H:6]1[CH2:5][CH2:4][C@@H:3]2[O:21][CH2:22][C:23]([OH:25])=[O:24]

Participants

4

Reactant 1

HCID 131719462HCID 131719462, compound

Product 1

HCID 86751697HCID 86751697, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

The unsaturated acid (3.2 g, from Step D) in glacial acetic acid (200 ml) and platinum oxide (1.0 g) was hydrogenated at 60° C. under 40 psi for 24 hours. The mixture was filtered through a pad of celite, and the filtrate concentrated to dryness. The residue was recrystallized from 5% MeOH in methylene chloride to yield the title acid.

Workup

  1. filtrationThe mixture was filtered through a pad of celite
  2. concentrationthe filtrate concentrated to dryness
  3. customThe residue was recrystallized from 5% MeOH in methylene chloride

Sources & evidence

ORD record
ord-0f2a21d41dcf4f28aec00aa2cdd2c02d
Source dataset
uspto-grants-1997_12
Patent number
US05693809

Reaction notes

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