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HRID1938929

反应详情

EQUATION

反应方程式

HRID 1938929 的结构方程式

REACTANTS

反应物

3
结构：[O-][I+3]([O-])([O-])[O-]
HCID167232

Periodate ion

IO4-

结构：CCSCCCCCCCCCCC(=O)OC(C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID9807943

未命名化合物

结构：[Na+].[O-][I+3]([O-])([O-])[O-]
HCID23667635

Sodium periodate

INaO4

PRODUCTS

生成物

1
结构：CCS(=O)CCCCCCCCCCC(=O)OC(C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID22870610

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
催化剂HCID962

Water

H2O

结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

To a stirred solution of 20-(11-(ethylthio)-undecanoyloxy)-4-methyl-5α-4-azapregnan-3-one (0.056 g, 0.1 mM) in acetone (5 mL) at room temperature was added a solution of sodium periodate (0.033 mg, 0.154 mM) in water (3 drops). After prolonged stirring with additional portions of the periodate added (0.046 g total) over 3 days, the solvents were removed in vacuo, and the residue extracted with methylene chloride. The methylene chloride was removed in vacuo, and the resulting residue was flash chromatographed on silica gel (30% acetone/methylene chloride eluant) to give the title compound as a glaze. MS M+ calculated for C34H59NO4 S, mw=577.90; observed m/e 577.

WORKUP

后处理

  1. additionadded (0.046 g total) over 3 days
  2. customthe solvents were removed in vacuo
  3. extractionthe residue extracted with methylene chloride
  4. customThe methylene chloride was removed in vacuo
  5. customchromatographed on silica gel (30% acetone/methylene chloride eluant)