Benzyl isocyanate → HCID 22870605, compound

Participants

Reaction Steps

To a solution of 17β-hydroxy-4-methyl-5α-4-azaandrostan-3-one (61 mg) in pyridine (0.60 ml) was added benzyl isocyanate (54 mg, 0.40 mmol). The mixture was stirred at 60°-70° C. under N2 for 18 hr and pumped in vacuo to remove pyridine. The residue was purified using a silica gel plate (2000 m) developed with ethyl acetate (Rf=0.37, run in EtOAc) to give the title compound; m.p. is 216°-217° C.

Provenance & Evidence