Methyl Isocyanate → HCID 22870584, compound

HRID 1938933Notes

Reaction equation

[CH3:1][N:2]=[C:3]=[O:4].[OH:5][CH2:6][CH:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:23]([CH2:24][CH2:25][C@:8]12[CH3:9])[C@:21]1([CH3:22])[C@H:16]([N:17]([CH3:27])[C:18](=[O:26])[CH2:19][CH2:20]1)[CH2:15][CH2:14]3.C(N=C=O)C1C=CC=CC=1>>[CH3:1][NH:2][C:3]([O:5][CH2:6][CH:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:23]([CH2:24][CH2:25][C@:8]12[CH3:9])[C@:21]1([CH3:22])[C@H:16]([N:17]([CH3:27])[C:18](=[O:26])[CH2:19][CH2:20]1)[CH2:15][CH2:14]3)=[O:4]

Participants

Reactant 3

HCID 12228Methyl Isocyanate

HCID 76639Benzyl isocyanate

HCID 22862543HCID 22862543, compound

Product 1

HCID 22870584HCID 22870584, compound

Procedure

Employing substantially the same procedure as described in Example 202, but substituting methyl isocyanate and 17-(hydroxymethyl)-4-methyl-5α-4-azaandrostan-3-one for the benzyl isocyanate and steroid alcohol, respectively, used therein, the title compound was obtained. MS M+2 calculated for C22H36 N2O3, mw=376.54; observed m/e 378.

Sources & evidence

ORD record: ord-49efe49834fb4486b0aea7f3317c1551
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05693809

Reaction notes

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