Methanol → HCID 21466888, compound

Participants

Reaction Conditions

Reaction Steps

13.2 g of glycylglycine, 200 ml of methanol, 20 g of triethylamine, and 15 g of carbon disulfide were placed in a flask having a capacity of 500 ml, and stirred at 30° C. for 1 hour. 12.3 g of ethyl chloroacetate dissolved in 50 ml of methanol was dropwise added thereto, then stirred at room temperature for 30 minutes. The obtained solution was yellowish orange. After the solvent was distilled off under reduced pressure, 50 ml of ethanol was added, and 15 g of potassium acetate dissolved in 300 ml of ethanol was further added thereto. The precipitated crystals were recovered by filtration, washed with ethanol to thereby obtain 15.4 g of rhodanine-3-ylmethylcarbamoylacetic acid.

Provenance & Evidence