HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 6-Methoxy-3-(1-piperazinyl)-1,2-benzisoxazole hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 3-Chloro-6-methoxy-1,2-benzoxazole | HCID 15816924 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-Methoxy-3-(1-piperazinyl)-1,2-benzisoxazole hemihydrate | HCID 69946912 | — |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
A mixture of 3-chloro-6-methoxy-1,2-benzisoxazole (3.0 g) and piperazine (6.0 g) was heated to 140° C. over 4 hours in a sealed tube and then cooled to room temperature. The contents of the tube were dissolved in MeOH and further diluted with EtOAc (1 L). The precipitate was filtered and the filtrate dried over MgSO4 and concentrated in vacuo. Flash chromatography (silica gel) eluting with 30% MeOH/EtOAc provided a residue upon evaporation (3.6 g, m.p. 79°-80° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696113 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-72a2df3a579f4a43aea5a60b55b7fae7 |
| Source note | uspto-grants-1997_12 |