Thionyl Chloride → 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride

HRID 1939203Notes

Reaction equation

HRID 1939203 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([C:12]([OH:14])=O)=[CH:9][CH:8]=1.S(Cl)([Cl:17])=O>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([C:12]([Cl:17])=[O:14])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 7364825-(Pyridin-2-yl)thiophene-2-carboxylic acid

Product 1

HCID 27761995-(2-Pyridinyl)-2-thiophenecarbonyl chloride

Procedure

A mixture of 1.0 g of 5-(2-pyridinyl)thiophene-2-carboxylic acid and 5 ml of thionyl chloride is refluxed for 2.5 hours. The mixture is concentrated to dryness under vacuum. Toluene is added (2 times) and the solvent removed under vacuum to give the product as a glass.

Workup

  1. temperatureis refluxed for 2.5 hours
  2. concentrationThe mixture is concentrated to dryness under vacuum
  3. additionToluene is added (2 times)
  4. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-fb975a4954c24bc19034a6d40549b73a
Source dataset
uspto-grants-1997_12
Patent number
US05696112

Reaction notes

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