反应详情

A mixture of 1.0 g of 5-(2-pyridinyl)thiophene-2-carboxylic acid and 5 ml of thionyl chloride is refluxed for 2.5 hours. The mixture is concentrated to dryness under vacuum. Toluene is added (2 times) and the solvent removed under vacuum to give the product as a glass.

1. temperatureis refluxed for 2.5 hours
2. concentrationThe mixture is concentrated to dryness under vacuum
3. additionToluene is added (2 times)
4. customthe solvent removed under vacuum