Triethylamine → HCID 21467140, compound

Participants

Reaction Steps

To a cooled (0° C.) mixture of 0.306 g of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine and 1.11 μl of triethylamine in 5 ml of dichloromethane is added 1.2 g of 6-[(2-methylphenylacetyl)amino]pyridine-3-carbonyl chloride. The mixture is stirred at room temperature for 16 hours and diluted with 50 ml of dichloromethane. The mixture is washed with H2O, 1N NaHCO3, H2O, brine and dried (Na2SO4). The solution is concentrated to dryness under vacuum and the residue chromatographed on silica gel to give the product as a solid.

Provenance & Evidence