Acetaldehyde, 2,2-dimethoxy- → HCID 21467216, compound

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Reaction Steps

A suspension of 4-methoxy-3-(4-methyl-1-piperazinyl) benzenamine (5 g, 0.023 mol) in ethanol (150 ml) and dimethoxyethanal (9.5 g, 1.2 eq) was hydrogenated over 10% Palladium on charcoal (3 g) at standard temperature and pressure for 3 h. The suspension was filtered through kieselguhr, washed with methanol and evaporated to give a pale yellow oil. Purification by Fcc, eluting with 2% methanol/dichloromethane afforded the title compound (6.64 g, 95%).

Provenance & Evidence