1,2-Dibromoethane → Ethyl 1-acetylcyclopropane-1-carboxylate

Participants

Reaction Steps

A mixture of 10.4 g of ethyl acetoacetate, 15 g of 1,2-dibromoethane, 23 g of potassium carbonate, and 150 ml of N,N-dimethylformamide (DMF) was stirred at room temperature for 2 days. An insoluble material was removed by filtration, and the filtrate was concentrated to dryness under reduced pressure. Water was added to the residue, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The resulting pale yellow oily substance was distilled under reduced pressure to give 7.5 g of ethyl 1-acetyl-1-cyclopropanecarboxylate as a fraction having a boiling point of 70° to 71° C./2-3 mmHg.

Provenance & Evidence