HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → 7-[3-(R)-Aminopyrrolidinyl]-6,8-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | 1-[(1R,2S)-2-Fluorocyclopropyl]-6,7,8-trifluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid | HCID 22879964 | — |
| Product | 7-[3-(R)-Aminopyrrolidinyl]-6,8-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid | HCID 22879968 | 66.1% |
Reaction Steps
A hundred milligrams of 6,7,8-trifluoro-1-[(1R,2S)-2-fluorocyclopropyl]-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 120 mg of (R)-3-t-butoxycarbonylaminopyrrolidine were reacted in the same manner as in Example 7, and the reaction mixture was worked up similarly to yield 80 mg of the titled compound as a grayish white to yellowish white substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696132 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-02ffca2aebc24538ac8a10fc355c536f |
| Source note | uspto-grants-1997_12 |