HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 53833634, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | HCID 67596392 | HCID 67596392 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 53833634 | HCID 53833634 | 88.6% |
Reaction Steps
A suspension of 3-[(2,2-di[4-chlorophenyl]-1,3-benzodioxolan-5-yl)methylcarbonyl]-1H-indole (8.9 g) (see Preparation 10) in 2-butanone (200 ml) was treated with anhydrous potassium carbonate (12.2 g) and ethyl 4-bromobutanoate (5.2 g). The mixture was heated under reflux for 16 hours, filtered and evaporated. Flash chromatography (silica, eluant=dichloromethane) gave the title compound as a crystalline solid (9.68 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696146 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-fb5410b92b3e4a4d9325bba64289e735 |
| Source note | uspto-grants-1997_12 |