Phosphorus oxide (P4O10) → HCID 21467609, compound

Participants

Reaction Steps

3.9 g (11 mmol) 2-acetyl-4-allyl-6,11-dihydro-3-hydroxy-8-methoxy-dibenz[b,e]oxepin-11-one is added at 100° C. to a mixture of 9.2 g phosphorus pentoxide and 6 ml ethanol, heated for 30 minutes to 140° C., poured onto ice and filtered. After chromatography on silica gel (eluting agent:ethyl acetate:isohexane 1:1) 0.9 g of the title compound (23% of theory) of melting point 159°-160° C. (from ether) is isolated.

Provenance & Evidence