HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 2-cyano-3-(1-methyl-2-chloro-3-indolyl)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-1-methyl-1H-indole-3-carbaldehyde | HCID 314792 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 2-cyano-3-(1-methyl-2-chloro-3-indolyl)acrylate | HCID 53731520 | — |
Reaction Steps
To 2 g of 1-methyl-2-chloroindole-3-carbaldehyde, dissolved in 50 ml of abs. EtOH, was added 2.3 g of ethyl 2-cyanoacetate and 4.2 g of triethylamine. After 19 hours with stirring, the solution was added to 200 ml of water, and the precipitate collected by filtration and dried to give (2a). Yield 2.68 g of (2a), m.p. 131°-132° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696148 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-e436ecccadf7426a8c8cc2e4a88a7258 |
| Source note | uspto-grants-1997_12 |