HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 54225821, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 21467573 | HCID 21467573 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54225821 | HCID 54225821 | — |
Reaction Steps
To 600 mg of 1-(4-methoxybenzyl)-2-chloroindole-carbaldehyde, slurried in 10 ml of ethanol, was added 608 mg of potassium carbonate and 0.24 ml of ethyl cyanoacetate. After overnight stirring 10 ml of water was added, and the product collected by filtration, washed with water, and dried to give (12a). Yield 620 mg of (12a). M.p. 153°-4° C. (sample recryst. from EtOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696148 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-ebe478deab3d4562bcb3f3f93100495c |
| Source note | uspto-grants-1997_12 |