Water ethanol → HCID 54084216, compound

HRID 1939393Notes

Reaction equation

HRID 1939393 reaction equation
[C:1]([C:3](=[CH:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH2:19][C:20]2[CH:25]=[CH:24][C:23](OC)=[CH:22][CH:21]=2)[C:11]=1[Cl:28])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].C[CH2:30][OH:31].O>>[C:1]([C:3](=[CH:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:31][CH3:30])[C:11]=1[Cl:28])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2]

Participants

3

Reactant 2

HCID 19096565Water ethanolHCID 54225821HCID 54225821, compound

Product 1

HCID 54084216HCID 54084216, compound

Procedure

To 600 mg of 1-(2-methoxybenzyl)-2-chloroindole-carbaldehyde, slurried in 10 ml of ethanol, was added 608 mg of potassium carbonate and 0.24 ml of ethyl cyanoacetate. After overnight stirring 10 ml of water was added, and the product collected by filtration, washed with water, and dried to give (12a). Yield 630 mg of (12a). M.p. 126°-8° C. (sample recryst. from EtOH/water).

Sources & evidence

ORD record
ord-be823c1c8b1344a69b7366e4fb45c865
Source dataset
uspto-grants-1997_12
Patent number
US05696148

Reaction notes

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