Nicotinic Acid → Zinc nicotinate

Temperature

80 °C

5.0 g of nicotinic acid was dissolved in 100 ml of deionized water with stirring in a hot bath. Similarly, 4.5 g of zinc acetate.2H2O was dissolved in 100 ml of deionized water in a hot bath and both were mixed with vigorous stirring. Subsequently, ammonia water (1:1 mixture of 25% ammonia water and distilled water) was added to adjust the pH to 8.5. The mixture was heated in a hot bath of about 80° C. for 10 minutes to complete the reaction, was continuously heated to concentrate the mixture, then being evaporated to about 20 ml. After cooling in a refrigerator, the precipitate was filtered with a No. 5B paper filter, and washed with deionized water. The obtained material was dissolved with heating in 200 ml of deionized water, followed by concentration to 20 ml. The concentrate was cooled down at room temperature, and washed three times with deionized water. The obtained material was dried sufficiently at 65° C. or lower temperature in an electric oven to obtain 3.0 g of zinc nicotinate (hereinafter abbreviated as Compound A).

1. additionboth were mixed with vigorous stirring
2. customthe reaction
3. temperaturewas continuously heated
4. concentrationto concentrate the mixture
5. custombeing evaporated to about 20 ml
6. temperatureAfter cooling in a refrigerator
7. filtrationthe precipitate was filtered with a No
8. filtration5B paper filter
9. washwashed with deionized water
10. dissolutionThe obtained material was dissolved
11. temperaturewith heating in 200 ml of deionized water
12. concentrationfollowed by concentration to 20 ml
13. temperatureThe concentrate was cooled down at room temperature
14. washwashed three times with deionized water
15. customThe obtained material was dried sufficiently at 65° C.

ORD record

ord-ffcbc5ccb0c04518be13a9a7f71ea248

Source dataset

uspto-grants-1997_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05696169