Nicotinamide → HCID 67342561, compound

HRID 1939403Notes

Reaction equation

HRID 1939403 reaction equation
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[Cl-].[Cl-].[Zn+2:12]>C(O)C>[Zn:12].[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 936NicotinamideHCID 3007855Zincchloride

Product 1

HCID 67342561HCID 67342561, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

4.89 g (0.04 mol) of nicotinamide is dissolved in 100 ml of ethanol, to which 2.73 g (0.02 mol) of ZnCl2 in 50 ml of ethanol is added and mixed. When stirred, white crystals immediately precipitate. The precipitate is filtered with a No. 5C filter paper, followed by washing with ethanol and then with diethyl ether. The washed product is allowed to stand for evaporating diethyl ether, and dried at 60° C. in an electric oven to obtain the desired compound.

Workup

  1. additionis added
  2. additionmixed
  3. customwhite crystals immediately precipitate
  4. filtrationThe precipitate is filtered with a No
  5. filtration5C filter paper
  6. washby washing with ethanol
  7. customfor evaporating diethyl ether
  8. customdried at 60° C. in an electric oven

Sources & evidence

ORD record
ord-4733ef3c791940778927abeeae96e0f6
Source dataset
uspto-grants-1997_12
Patent number
US05696169

Reaction notes

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