Trimethyl borate → 5-Chloro-2-methoxyphenylboronic acid

Participants

Reaction Steps

This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 2-bromo-4-chloroanisole (2.00 g, 9.01 mmol, 1.0 equivuiv), n-BuLi (2.5M in hexanes; 3.62 mL, 9.01 mmol, 1.0 equivuiv), and trimethylborate (3.0 mL, 26 mmol, 2.9 equivuiv) to afford 1.30 g (77%) of crude 5-chloro-2-methoxyphenylboronic acid as a white semi-solid. This compound was used in the next reaction with no further purification.

Provenance & Evidence