反应详情

To a mixture of N-(6-chloro-3-pyridylmethyl)-S-methyl-N'-nitroisothiourea (1.3 g) and acetonitrile (10 ml) was added pyridine (1.6 g) and further dropwise acetyl chloride (0.79 g) under ice-cooling. After stirring for 1 hour under ice-cooling, the mixture was warmed to room temperature and stirred at the same temperature for 2 hours. The reaction mixture was concentrated and 50 ml of ether and 5 ml of 2N hydrochloric acid were added to the mixture which was then partitioned. The resultant organic layers were dried over anhydrous magnesium sulfate and concentrated to afford 1.6 g of N-acetyl-N-(6-chloro-3-pyridylmethyl)-S-methyl-N'-nitroisothiourea as a red oil.

1. temperaturecooling
2. temperaturecooling
3. stirringstirred at the same temperature for 2 hours
4. concentrationThe reaction mixture was concentrated
5. addition50 ml of ether and 5 ml of 2N hydrochloric acid were added to the mixture which
6. customwas then partitioned
7. dry with materialThe resultant organic layers were dried over anhydrous magnesium sulfate
8. concentrationconcentrated