HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Bromo-2'-fluoroacetophenone | HCID 2737449 | — |
| Reactant | 4-Amino-6-carboethoxy-5,6,7,8-tetrahydro-2(1H)-quinazolinone | HCID 15284093 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one | HCID 9928570 | — |
Reaction Steps
A solution of 4-Amino-6-carboethoxy-5,6,7,8-tetrahydro-2(1H)-quinazolinone (262 mg) and 2'-fluoro-bromoacetophenone (217 mg) in dry DMF (10 mL) was refluxed under nitrogen for 1.5 h. The solution was cooled and 40 mL water is added. The precipitate was collected and washed successively with 10 mL of methanol and 20 mL hot ethyl acetate to yield 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (Compound 1), m.p. 257°-277° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696260 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-1b682796b6724d32b7fab62666effc95 |
| Source note | uspto-grants-1997_12 |