Glycine → HCID 178446845, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of glycine (18.77 g, 0.25 mol) in methanol (80 ml) and water (4.5 ml) was cooled to 0° C. and adjusted to pH 9.6 by adding 30 percent strength sodium hydroxide solution. Methyl pentanimidate (68.81 g of a 42 percent strength solution in toluene=0.25 mol) was added to this suspension over the course of 5 minutes. After stirring for 18 hours at room temperature, the suspension was filtered, and the filter cake was washed with toluene (75 ml) and dried. The yield of the title compound was 25.45 g (purity>95 percent by H-NMR), 64 percent based on glycine. Other data concerning the title compound was:

Provenance & Evidence