HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylthio-1-methylamino-2-nitroethylene → (1E)-N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylthio-1-methylamino-2-nitroethylene | HCID 123549 | — |
| Reactant | 5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine | HCID 162203 | — |
| Product | (1E)-N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine | HCID 3001055 | 90.6% |
Reaction Steps
The process of Example 1 was repeated at a commercial scale, using 2-[[[5-(Dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (35 kg) and N-methyl-1-(methylthio)-2-nitroetheneamine (28 kg) to give crude ranitidine base (46.5 kg), m.p. 68°-70° C.; purity--99.1% (HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696275 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-3b8ca146a7264aef80fdb3ad038243b5 |
| Source note | uspto-grants-1997_12 |