HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tris(furan-2-yl)phosphane → 2,4-Diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tris(furan-2-yl)phosphane | HCID 521585 | — |
| Reactant | 5-Iodo-6-methylpyrimidine-2,4-diamine | HCID 15855792 | — |
| Reactant | 1-Oxo-1-(4-chlorophenyl)-3-tributylstannyl-2-propene | HCID 67632895 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,4-Diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine | HCID 53794185 | — |
Reaction Steps
This compound is prepared in a manner analogous to that of Step E of Example 4, using 2.9 grams of (0.0064 mole) of 1-oxo-1-(4-chlorophenyl)-3tributylstannyl-2-propene, 1.2 grams (0.0048 mole) of 2,4-diamino-5-iodo-6-methylpyrimidine (prepared in Step B Example 3), 0.04 gram of tri-2-furylphosphine and 0.04 gram (catalyst) of tris(dibenzylidineacetone)dipalladium(0) in 30 mL of N,N-dimethylformamide, yielding 2,4-diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05696259 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-833fbbe8d1ab4b9990c89c29d7643524 |
| Source note | uspto-grants-1997_12 |