HCID 21468036, compound → HCID 22880064, compound

Participants

Reaction Steps

Palladium hydroxide on carbon (20%, 10 g) was added to a solution of 4-O-benzyl-2-O-(diisopropylphosphonomethyl)-1-O-methoxymethyl-1,2,4-butanetriol (21.9 g, 52.33 mmol) in a mixture of ethanol and cyclohexene (200 mL of each). The resulting mixture was heated at reflux for 6 hours. The mixture was cooled to room temperature and filtered. The filtrate was evaporated and the residue was purified by flash chromatography on silica gel (methylene chloride:methanol=20:1 to 10:1) to give 16.79 g (98% yield) of the title compound as an oil.

Provenance & Evidence