Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- → HCID 86751716, compound

Participants

Reaction Steps

(S)-2-O-(Diisopropyl phosphonomethyl)-1-O-methoxymethyl-3-butene-1,2-diol (3.45 g, 11.12 mmol) and camphorsulfonic acid (0.2 g, 0.8 mmol) were mixed in 45 mL of methanol. The resulting solution was heated at reflux for 5 hours. The solvent was evaporated, and the residue was purified by flash chromatography (ethyl acetate:petroleum ether=1:1 to 1:0 then ehtyl acetate:methanol 20:1) to give 2.73 g (92%) of the title compound as an oil.

Provenance & Evidence