Hexane → 1-Phenylethanol, (R)-
Reaction equation
[CH2:1]([OH:15])[CH2:2]CCCCCCCCCCCC.[CH3:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>>[C:18]1([C@H:1]([OH:15])[CH3:2])[CH:17]=[CH:16][CH:21]=[CH:20][CH:19]=1Participants
3
Conditions
- Temperature
- 50 °C
Procedure
To the distillation residue were added 270 g of n-tetradecanol, 450 ml of hexane, and 10 g of Lipase OF. After regulating the particle size of the lipase by ultrasonication in the same manner as above, the mixture was stirred at 50° C. and 350 rpm for 72 hours to carry out interesterification. Hexane was evaporated under reduced pressure from the reaction mixture, and the residue was subjected to simple distillation at 90° C. and 3 mmHg to give highly pure (R)-(+)-1-phenylethanol in a free form (yield: 87%; chemical purity: 100%; optical purity: 100% ee).
Workup
- customby ultrasonication in the same manner as above, the mixture
- customHexane was evaporated under reduced pressure from the reaction mixture
- distillationthe residue was subjected to simple distillation at 90° C.
Sources & evidence
- ORD record
- ord-304fe2d187d94e39aeecf8bd056bbabe
- Source dataset
- uspto-grants-1997_12
- Patent number
- US05696299
Reaction notes
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