Water → (+)-2-Octanol

Interesterification was carried out in the same manner as in Example 9, except for replacing dimethyl tetradecadicarboxylate with 140 g of dimethyl decamethylenedicarboxylate at 80° C. for 25 hours. The water content of the reaction system was 0.04% by weight, and 95% of the lipase particles had a particle size of 20 to 60 μm. Gas chromatography of the reaction mixture revealed that 58 mol % of (R,S)-2-octanol had been converted to its decamethylenedicarboxylic acid ester. The reaction mixture was treated in the same manner as in Example 9 to remove lipase, and the filtrate was subjected to simple distillation at 95° C. and 3 mmHg. However, it was impossible to isolate (S)-(-)-2-octanol with high purity due to co-distillation of other components.

1. customat 80° C.
2. customfor 25 hours
3. additionThe reaction mixture was treated in the same manner as in Example 9
4. customto remove lipase
5. distillationthe filtrate was subjected to simple distillation at 95° C.

ORD record

ord-4c0d3db646b34dc5b0ff1578e60e58ad

Source dataset

uspto-grants-1997_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05696299