Isopropyl Stearate → (S)-(+)-2-Decanol

Temperature

85 °C

In a 300 ml separable flask were put 1 g of Lipase PL, and 40 g of (R,S)-2-decanol, and the mixture was subjected to ultrasonication with the same ultrasonic wave generating equipment as used in Example 1 at room temperature and 90 kHz for 1 minute. To the mixture was added 60 g of isopropyl stearate, followed by stirring at 85° C. and 250 rpm for 30 hours to carry out interesterification. The water content of the reaction system was 0.02% by weight, and 96% of the lipase particles had a particle size of 10 to 40 μm. Gas chromatographic analysis of the reaction mixture revealed that 57 mol % of (R,S)-2-decanol had been converted to 2-decyl stearate. Lipase was removed by filtration in the same manner as in Example 8, and the filtrate was subjected to simple distillation at 70° C. and 5 mmHg to recover unreacted (S)-(+)-2-decanol (yield: 73.5%; chemical purity: 99.9%; optical purity: 93% ee).

1. customIn a 300 ml separable flask were put
2. customas used in Example 1 at room temperature
3. wait250 rpm for 30 hours to carry out
4. customLipase was removed by filtration in the same manner as in Example 8
5. distillationthe filtrate was subjected to simple distillation at 70° C.

ORD record

ord-3cef74ef0e8b49e485f41a429ef145a5

Source dataset

uspto-grants-1997_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05696299