Stearyl Alcohol → 1-Phenylethanol, (R)-

Participants

Reaction Conditions

Reaction Steps

To the distillation residue were added 270 g of stearyl alcohol and 10 g of Lipase PL. The mixture was subjected to ultrasonication in the same manner as described above to regulate the particle size of the lipase in such a manner that 95% or more of the particles had a particle size of 20 to 50 μm. The water content of the reaction system was 0.04% by weight. The mixture was stirred at 90° C. and 350 rpm under reduced pressure of 3 mmHg for 12 hours to carry out interesterification while recovering the distillate to obtain highly pure (R)-(+)-1-phenylethanol (yield: 96%; chemical purity: 100%; optical purity: 100% ee).

Provenance & Evidence