1-(2-Bromophenyl)ethyl behenate → 1-(2-Bromophenyl)ethan-1-ol

Participants

Reaction Steps

Interesterification was carried out by using 3 g of Lipase QL, 50 g of (R,S)-1-(2-bromophenyl)ethanol, and 150 g of tribehen at 120° C. for 20 hours in the same manner as in Example 12. The water content of the reaction system was 0.01% by weight, and 90% of the lipase particles had a particle size of 30 to 50 μm. Gas chromatography of the reaction mixture revealed that 44 mol % of (R,S)-1-(2-bromophenyl)ethanol had been converted to 1-(2-bromophenyl)ethyl behenate. The reaction mixture was treated in the same manner as in Example 12, and the filtrate was subjected to simple distillation at 110° C. and 5 mmHg to recover unreacted (S)-(-)-1-(2-bromophenyl)ethanol (yield: 88%; chemical purity: 99.9%; optical purity: 99% ee or higher).

Provenance & Evidence