Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-Diazo-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 5-Bromo-1-diazo-3-(3,4-dichlorophenyl)-2-pentanone | HCID 53781276 | — |
| 생성물 | 1-Diazo-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone | HCID 53915725 | — |
반응 단계
Dissolve the product of Step 4 (3.93 g, 11.7 mmoles) in 50 ml of dry EtOAc. Add 4-hydroxy-4-phenyl-1-piperidine (2.55 g, 14.4 mmoles), followed by dry Et3N (13.3 ml.). Heat under N2 at 60°-65° C. for 28 h. Cool to room temperature, filter the solid and wash with EtOAc. Apply the filtrate to a silica gel column and elute the column with 1.5% CH3OH(NH3)/ETOAc. Yield: 2.34 g; Cl-MS: m/e=432 (M+H+, 35C1 +37Cl isotope).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05696267 |
| 출처 데이터셋 | uspto-grants-1997_12 |
| ORD ID | ord-5d63b494921f4fdda418128267213273 |
| 출처 메모 | uspto-grants-1997_12 |