L-Glutamic Acid → p-Toluenesulfonic acid

Participants

Reaction Steps

A mixture of N,N-Bis(2'-methoxyethyl)-6-hydroxyhexanamide (10.0 g, Example 5), L-glutamic Acid (2.97 g) and p-toluenesulfonic acid monohydrate (4.03 g) in toluene (30 mL) was refluxed under nitrogen. Water was separated from the distillate in a Barrett distilling receiver. When the theoretical amount of water (1.1 g) was collected, the heating was stopped and the toluene removed in vacuo on a rotary evaporator. The product was obtained as its p-toluenesulfonate salt as a brown oil (15.51 g).

Provenance & Evidence