3-Methylglutaric anhydride → HCID 86751727, compound

HRID 1939868Notes

Reaction equation

HRID 1939868 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH:9]=[C:10]([Cl:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].[CH3:17][CH:18]1[CH2:24][C:23](=[O:25])[O:22][C:20](=[O:21])[CH2:19]1>ClCCl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:23](=[O:25])[CH2:24][CH:18]([CH3:17])[CH2:19][C:20]([OH:22])=[O:21])=[CH:4][C:3]=1[CH:9]=[C:10]([Cl:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 778283-Methylglutaric anhydrideHCID 54470085HCID 54470085, compound

Product 1

HCID 86751727HCID 86751727, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

5.2 g of 4-chloro-3-(2-chloro-2-ethoxycarbonyl-ethenyl)aniline in 30 ml of dichloromethane were added dropwise at 25° C. to a solution of 2.56 g of 3-methylglutaric anhydride in 50 ml of dichloromethane. After 3 h, the deposited precipitate was removed and washed with dichloromethane. Yield: 5 g; m.p.: 137°-138° C.

Workup

  1. customthe deposited precipitate was removed
  2. washwashed with dichloromethane

Sources & evidence

ORD record
ord-97d778ca0d3c47e7a5a4b23ae6020e0d
Source dataset
uspto-grants-1997_12
Patent number
US05698494

Reaction notes

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