46133-38-4 → HCID 12131338, compound

HRID 1939874Notes

Reaction equation

HRID 1939874 reaction equation
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[N:5]=1)#[N:2]>CO.[Ni]>[NH2:2][CH2:1][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][NH2:12])[N:5]=1

Participants

4

Reactant 1

HCID 58269246133-38-4

Product 1

HCID 12131338HCID 12131338, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2,6-bis(cyanomethyl)pyridine (4.3 g, 27 mmol) in methanol (75 ml, saturated with ammonia) was added Raney nickel (10.0 g, excess) and the mixture hydrogenated at 45 psi and room temperature for 48 hours. The catalyst was filtered off and the solvent evaporated in vacuo to give 2,6-bis(2-aminoethyl)pyridine as a brown viscous oil (3.7 g, 83%). This was used without further purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-1ed6c26f3d85450ebdb7a193f29c0e46
Source dataset
uspto-grants-1997_12
Patent number
US05698546

Reaction notes

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