HCID 18977173, compound → HCID 18977140, compound

HRID 1939917Notes

Reaction equation

HRID 1939917 reaction equation
I([O-])(=O)(=O)=[O:2].[Na+].[CH3:7][S:8][CH2:9][CH2:10][S:11]([NH:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27](=[O:30])[NH:28][N:29]=2)=[CH:20][CH:19]=1)(=[O:13])=[O:12]>C(O)(=O)C>[CH3:7][S:8]([CH2:9][CH2:10][S:11]([NH:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27](=[O:30])[NH:28][N:29]=2)=[CH:20][CH:19]=1)(=[O:13])=[O:12])=[O:2]

Participants

4

Reactant 2

HCID 18977173HCID 18977173, compoundHCID 23667635Sodium periodate

Product 1

HCID 18977140HCID 18977140, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

An aqueous solution (25 ml) containing 3.20 g of sodium metaperiodate was added dropwise to an acetic acid suspension (100 ml) containing 5.36 g of 6-[4-(3-(2-methylthioethyl)sulfonylaminopropyl)phenyl]pyridazin-3(2H)-one, and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and precipitated crystal was collected by filtration and dried to obtain 5.00 g of 6-[4-(3-(2-methylsulfinylethyl)sulfonylaminopropyl)phenyl]pyridazin-3(2H)-one.

Workup

  1. customprecipitated crystal
  2. filtrationwas collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-fc1c7462d067463892c3af0d8581c09c
Source dataset
uspto-grants-1997_12
Patent number
US05698554

Reaction notes

Loading…