Nicotinic Acid → HCID 18977183, compound

HRID 1939932Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([C:13]2[CH2:14][CH2:15][C:16](=[O:19])[NH:17][N:18]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[C:20](O)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:13]2[CH2:14][CH2:15][C:16](=[O:19])[NH:17][N:18]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:20]([C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)=[O:27]

Participants

Reactant 2

HCID 938Nicotinic Acid

HCID 18977162HCID 18977162, compound

Product 1

HCID 18977183HCID 18977183, compound

Procedure

By treating 6-[3-methyl-4-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one and nicotinic acid in the same manner as in Example 87, 6-[3-methyl-4-[4-(pyridin-3-ylcarbonylamino)butyl]phenyl]-4,5-dihydropyridazin-3(2H)-one was obtained.

Sources & evidence

ORD record: ord-ed59f7d33da243d58cf13ab0a6c8dd13
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05698554

Reaction notes

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