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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1939940Generated: November 3, 2026

Chloroacetyl chloride → 5-(2-Chloro-acetyl)-1,3-dihydro-benzoimidazol-2-one

https://huagongshe.com/reaction/1939940

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloroacetyl chlorideHCID 6577—
Reactant2-Hydroxy benzimidazoleHCID 11985—
ReactantHCID 21465145HCID 21465145—
Product5-(2-Chloro-acetyl)-1,3-dihydro-benzoimidazol-2-oneHCID 2402659—

Reaction Steps

from 5-(2-(3-benzylpiperidino)-1-oxoethyl)-2,3-dihydrobenzimidazol-2-one ("K"; obtainable by reaction of 2,3-dihydrobenzimidazol-2-one with chloroacetyl chloride to give 5-chloroacetyl-2,3-dihydrobenzimidazol-2-one ("L"), then reaction with 3-benzylpiperidine):

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05698553
Source datasetuspto-grants-1997_12
ORD IDord-1ef115a3832f4f578d279a817476ba71
Source noteuspto-grants-1997_12