2(3H)-Benzoxazolone → 2(3H)-Benzoxazolone, 6-(chloroacetyl)-

HRID 1939941Notes

Reaction equation

HRID 1939941 reaction equation
C(C1CCCN([CH2:14][C:15]([C:17]2[CH:26]=[CH:25][C:20]3[NH:21][C:22](=[O:24])[O:23][C:19]=3[CH:18]=2)=[O:16])C1)C1C=CC=CC=1.O1C2C=CC=CC=2NC1=O.[Cl:37]CC(Cl)=O>>[Cl:37][CH2:14][C:15]([C:17]1[CH:26]=[CH:25][C:20]2[NH:21][C:22](=[O:24])[O:23][C:19]=2[CH:18]=1)=[O:16]

Participants

4

Reactant 3

HCID 60432(3H)-BenzoxazoloneHCID 6577Chloroacetyl chlorideHCID 21465142HCID 21465142, compound

Product 1

HCID 19889812(3H)-Benzoxazolone, 6-(chloroacetyl)-

Procedure

from 6-(2-(3-benzylpiperidino)-1-oxoethyl)-2,3-dihydrobenzoxazol-2-one ("P"; obtainable by reaction of 2,3-dihydrobenzoxazol-2-one with chloroacetyl chloride to give 6-chloroacetyl-2,3-dihydrobenzoxazol-2-one ("Q"), then reaction with 3-benzylpiperidine):

Sources & evidence

ORD record
ord-570f0f2d6fc948bc854e0abcb68d4be6
Source dataset
uspto-grants-1997_12
Patent number
US05698553

Reaction notes

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